Ole Gunnar Solskjaer saw Manchester United's lengthy trip to the Turkish capital bear no fruit, after his side were beaten to the punch by a team spearheaded by former Premier League star Demba Ba.
It was Ba who opened the scoring for the hosts, racing the full length of the pitch after United piled every man forward during an early attacking onslaught.
Ba made the Red Devils pay with a cool finish, before Edin Visca hammered home an effort shortly after to double the margin, courtesy of Ba's creative dummy.
Anthony Martial headed United back into the tie to offer a glimmer of hope at 2-1, but the hosts held firm to take three points which see Group H blown wide open.