Ole Gunnar Solskjaer's men are determined to put things right in the Black Country, after suffering a recent 2-1 defeat at the same venue in the Emirates FA Cup quarter-final.
As Wolves also took a point from a 1-1 draw at Old Trafford, it is clear the Reds are due a top performance against Nuno Espirito Santo's side.
With this fixture brought forward from the weekend due to Wolves' FA Cup semi-final with Watford on Sunday, it could provide another vital step in helping United claim a top-four place in the Premier League and, hence, confirm qualification for next season's Champions League.