Ole Gunnar Solskjaer's side travel to Luton Town on Tuesday night, hoping to go a step further than in 2019/20, when the Reds reached the semi-finals but were beaten 3-2 on aggregate by Manchester City, the eventual winners, despite victory in the second leg at the Etihad Stadium.
Ahead of the third-round Carabao Cup tie, we take a look at some of the stats and facts from our history in the competition...
FIRST GAME
It all started for United in the League Cup with a 1-1 draw at Exeter's St James Park in 1960.