The Reds have already confirmed at least a place in the play-offs, which begin in the new year, but the contest in Italy will help decide whether we are seeded or unseeded in the next round.
There’s still a slight chance that Marc Skinner’s side could finish in the top four, and qualify automatically for the quarter-finals, although we would need several results to go our way.
Find out more about all the permutations, plus TV info and team news, in our in-depth preview…
HOW TO WATCH AND FOLLOW
As with all of this season’s games, Wednesday’s clash is being broadcast live on Disney+, at 20:00 GMT, but don’t forget about MUTV’s offering.