Ralf Rangnick will take his side across town on Sunday afternoon hoping to boost our hopes of a top-four place following the setback of being held to a goalless draw by Watford last weekend.
Many pundits believe City are strong favourites to come out on top and complete the double after their 2-0 win at Old Trafford in November.
However, despite the 19-point gap in the table, there is every reason to believe the Reds can upset the formbook again.
The fact is United have won over half of our games against the Blues at the stadium they moved to from Maine Road in 2003.