Erik ten Hag's team have played Eddie Howe's side in the Premier League and Carabao Cup already this term, and the upcoming clash between the sides holds a lot of significance.
The Tynesiders sit three points above the Reds in the table, with two games to go. Victory for Erik ten Hag's men on Wednesday would eliminate that deficit, although Newcastle have a superior goal difference, and ensure we can still qualify for European football, depending on what happens on the final day of the league campaign.
Ahead of the fixture, which was rearranged from April due to our progression in the Emirates FA Cup, find out how you can watch and follow the action below.