The United legend was, of course, our caretaker boss in the autumn, guiding the Reds to two victories over the East Midlanders.
Now he's back in the opposite dugout and Ruben Amorim is the man in charge at Old Trafford, as we look to become the first side to confirm a spot in the last 16.
Here's the lowdown ahead of Friday's 20:00 GMT start...
HOW TO WATCH AND FOLLOW
United v Leicester will be shown live on ITV1, STV, ITVX and the STV Player in the UK.
As usual, MUTV will have full coverage of the build-up and the aftermath from pitchside and the Old Trafford studio, so join us from 18:55 GMT.