The Reds come into the Old Trafford encounter off the back of Saturday's thrilling 2-1 win over Crystal Palace in M16, after goals from Bruno Fernandes and Marcus Rashford ensured a huge three points.
Influential midfielder Casemiro was sent off for violent conduct against the Eagles, with Jeffrey Schlupp pulling a goal back for Patrick Vieira's side shortly after our no.18's dismissal.
The Reds, who are currently third in the Premier League, will hope to continue our superb run of form at home in all competitions, with last weekend's victory our 13th straight home success dating back to October.