Ruben Amorim's team will be looking to bounce back from a difficult afternoon on the road against Brentford last time out.
This game will be the first time we've faced the Black Cats since 2017, following their promotion from the Championship last season.
Here's everything you need to know about the upcoming fixture...
This game will not be available to watch live in the UK due to regulations that prevent 15:00 BST kick-offs being broadcast.
Despite that, we still have plenty of ways for you to keep up with the action if you're not at Old Trafford on Saturday, with our regular Matchday Live show starting at 13:55 BST, bringing you all the exclusive pre-match build-up, half-time analysis and post-match reaction you need.