Ole Gunnar Solskjaer's men will be bidding to return to winning ways following the disheartening derby defeat to Manchester City at Old Trafford two weeks ago, and the hope is that the international interlude will have had a refreshing effect.
Watford have endured their own difficulties, too, with Claudio Ranieri replacing Xisco Munoz as manager last month, and the Hornets just a couple of points above the relegation zone heading into this round of fixtures.
The circumstances around both sides' campaigns mean Saturday's match is likely to be a tense and dramatic one, with three points absolutely vital to each club.