Ralf Rangnick's side are bidding to register consecutive Premier League victories after defeating Norwich City 3-2 at Old Trafford on Saturday, and three points against Liverpool would really strengthen our push for a Champions League place.
But the hosts will also be in buoyant mood, having defeated Manchester City on Saturday to progress to the Emirates FA Cup final.
As the clash with one of our fiercest rivals approaches, here's all the important information you need...
HOW TO WATCH
Tuesday's encounter with Jurgen Klopp's side will be broadcast live in the UK on Sky Sports Main Event and Sky Sports Premier League, with coverage scheduled to begin at 19:00 BST.