The Reds have faced the French side just four times previously and are currently unbeaten against the Ligue 1 outfit, winning two and drawing two.
Though not regular opponents of United, there will still be some familiar faces on the touchline as they are currently under the guidance of former Reds defender Laurent Blanc. Argentinian defender Nicolas Tagliafico also joined their ranks last term, having previously worked under Erik ten Hag at Ajax.
Ahead of our second instalment of pre-season action, we’re taking a look back at our meetings with Lyon over the years, all of which came in the UEFA Champions League.