Manchester United head coach Ruben Amorim has challenged his players to grasp the opportunities that will arise when Amad, Noussair Mazraoui and Bryan Mbeumo compete at the Africa Cup of Nations.
The tournament in Morocco begins on 21 December and ends on 18 January.
That means our participants could miss up to six Premier League fixtures: Aston Villa (A), Newcastle (H), Wolverhampton Wanderers (H), Leeds (A), Burnley (A) and Manchester City (H).
During a press conference at Carrington on Thursday afternoon, Ruben was asked about the prospect of losing his African players at a crucial stage of the season.