The Morocco winger was a key member of Ten Hag's outstanding Ajax side before joining Chelsea in 2020. A loan move was agreed to send him to Istanbul in the summer but he has sustained what was described as a minor injury.
Nonetheless, despite hopes he would be available for the Group A encounter, the 30-year-old has not been named in the 19-man travelling squad.
There is still a wealth of talent and experience for coach Okan Buruk to select from, including ex-Red Wilfried Zaha, who scored against Ankaragucu in the Super Lig on Saturday.