The Reds head into the 14:00 GMT kick-off full of confidence, after beating Istanbul Basaksehir 4-1 at Old Trafford in midweek. Goals from Bruno Fernandes (two), Marcus Rashford and Daniel James secured three important points in Champions League Group H.
Ole Gunnar Solskjaer will hope his side will be able to produce a similar display against Ralph Hasenhüttl’s team, who sit fifth in the Premier League table.
A victory at St Mary’s would set a new all-time club record of eight straight away league wins. We’re currently on seven, level with the marker set under Sir Alex Ferguson between April and August 1993.