The Brazil international has fond memories of taking on the Yorkshiremen, as he has scored home and away against our rivals from across the Pennines.
He netted in both Premier League fixtures with the Whites last term, in the 5-1 win at Old Trafford and 4-2 triumph at Elland Road.
As he looks to add to his tally of four strikes in 2022/23, and build on another impressive display in the tense 2-1 victory against Crystal Palace last weekend, Fred discussed the magnitude of the fixture.
"Games against Leeds are another 'clasico' of English football, a really important derby," Fred told club media in an exclusive interview, which featured in United Review.