United sit bottom of Group A ahead of kick-off in Istanbul (17:45 GMT), but can rise to second with victory over the Turkish champions if FC Copenhagen fail to beat Bayern Munich.
With Marcus Rashford suspended due to a red card in our previous group-stage game – the dramatic 4-3 defeat to the Danes – the boss has been forced to reshuffle the line-up that won 3-0 at Goodison Park on Sunday.
The Reds have made a total of four changes, with Rasmus Hojlund declared fit enough to lead the line in a bid to add to his five goals in the competition, including a double against this evening's opponents on matchday two.