The Reds' reward for knocking Arsenal out last Sunday is an Old Trafford encounter with Ruud van Nistelrooy's Foxes side, with the game starting at 20:00 GMT.
It kicks off the television coverage of the latest stage of the famous competition, with ITV showing the action from M16 in the UK.
United, the holders, also played Leicester in the fourth round of the Carabao Cup earlier this term, winning 5-2, with van Nistelrooy in the home dugout, during his interim spell in charge of the team.
The East Midlanders may be struggling in the Premier League but they romped past Queens Park Rangers 6-2 in their tie last weekend.