The Stamford Bridge clash will now kick off at the later time of 20:15 BST, after originally being scheduled for 20:00 BST.
It will still be shown live on Sky Sports as the home side look to clinch a top-five place in order to play Champions League football next season, while this is the Reds' final away assignment of 2024/25.
The reverse fixture at Old Trafford finished 1-1 in November, with Bruno Fernandes and Moises Caicedo the two goalscorers.
United will be hoping the match comes before a Europa League final date on the following Wednesday (21 May), providing we can overcome Athletic Club on Thursday night, with Ruben Amorim's men three goals up from the first leg in Bilbao.