The games leading up to that milestone have taken in some great – and, occasionally, not-so-great – days out for United, but it is, nonetheless, a big milestone.
To celebrate, Inside United spoke to fans in their last edition about their most vivid memories of trips to see their side face the Merseysiders.
As we warm up to what will hopefully be a positive 100th visit, we've collated a selection of their tales.
Pete Molyneux, a legendary Red behind the infamous 'Ta ra, Fergie' banner in 1989, said: "My oldest memory is October 1968.