The club issued a statement on Monday afternoon confirming a COVID-19 outbreak has led to first-team operations at the training ground in Carrington being closed.
However, due to the different bubbles the teams are kept in, the Under-18s are able to play their eagerly anticipated fixture.
For those who have not already bought tickets for the third-round tie, the match is being shown live on MUTV.
The two sides are competing for the right to face Reading in the next round of the competition, with that fixture due to be played before 15 January 2022.