Marcus Rashford's 93rd-minute goal gave United victory at home to Nuno Espirito Santo's side back in December as Ole Gunnar Solskjaer's side rose closer to the top of the table during the festive period. The boss will be looking closely at any stand-out performers in Sunday's clash as he prepares to send United out for a European final on Wednesday.
First, though, is a difficult challenge as Wolves welcome their fans back to Molineux for the first time since the outbreak of COVID-19 more than a year ago.
Here's everything you need to know about Sunday's game.