The Dutchman was pleased with his side's performance in the 4-1 success against Melbourne Victory on Friday – a result that was secured without the services of the experienced pair.
De Gea was substituted during the second half of the 4-0 win over Liverpool earlier in the week, after pulling up when stretching to catch a ball just inside his box. He was subsequently rested from the game at the Melbourne Cricket Ground.
Varane was also absent from the squad for the Victory clash, after going to ground in some discomfort against the Merseysiders. The Frenchman was replaced in the starting XI by club captain Harry Maguire, who had recovered from a knock of his own.