Reds boss Ole Gunnar Solskjaer could have a number of options available for the visit of the Seagulls, who won their last two matches before the break.
David De Gea and Dean Henderson have both been away with their respective countries, Spain and England, but did not get any World Cup qualifier minutes under their belts. The two will be competing for the gloves again after Henderson played the last six games before the break.
At the back, Harry Maguire scored a late winner for England, against Poland, while Luke Shaw also reappeared for the Three Lions, in the victory in Albania.