Luke Shaw could make his comeback after being forced to pull out of our last match, the Premier League draw with Tottenham on 14 January.
The England left-back trained with the squad at Carrington on Tuesday, alongside club and international colleague Harry Maguire, who has been absent since the final UEFA Champions League group game against Bayern Munich.
With Lisandro Martinez coming off the bench in the Spurs game, there would appear to be more defensive options available to the manager.
Anthony Martial is definitely out, with a groin operation set to sideline the striker for a lengthy period, expected to span around 10 weeks.