The influential South Korea forward is representing his country in the Asian Cup in Qatar, so will miss the 16:30 GMT kick-off.
United could also be without some big names, with at least 12 players confirmed as unavailable for Monday night's Emirates FA Cup victory at Wigan Athletic.
Antony (injury), Amad and Christian Eriksen (both ill) were the newest absentees at the DW Stadium.
Eriksen and Luke Shaw, who has been out since the pre-Christmas defeat at West Ham United, are hoping to feature at the weekend. Eriksen, of course, is a former Spurs player.