Bruno Fernandes has played in 49 of United's 51 games in all competitions this season, but he will have to sit this one out through suspension, after he was booked in the first half of last week's encounter.
The Reds will also be without arguably our first-choice centre-back pairing.
Lisandro Martinez is out for the season following the metatarsal fracture he suffered in the closing stages of Sevilla's visit, while Raphael Varane will spend a few weeks on the sidelines.
Victor Lindelof and Harry Maguire successfully replaced the injured pair in the back four for Sunday's 2-0 win over Nottingham Forest.