Erik ten Hag's side tackle Paul Ince's Championship outfit in the fourth round of the Emirates FA Cup, with the tie kicking off at 20:00 GMT on Saturday evening, to accommodate live coverage on ITV4.
With the game coming between the two legs of the Carabao Cup semi-final against Nottingham Forest, and United three goals to the good following the first assignment at The City Ground, it is another opportunity for the Reds to impress and continue fighting on all fronts.
Harry Maguire is available again after serving a one-match Carabao Cup ban in midweek.