The Reds can clinch qualification for the knockout stages by beating the Serbian side but there is also another home match, against Brighton & Hove Albion in the Premier League, on the horizon, with Sunday's fixture the last before the international break.
It means there could be some juggling involved when it comes to selecting squads for the two games at Old Trafford.
Captain Ashley Young is suspended for the Brighton clash, after picking up a fifth booking during the defeat at Bournemouth, which could mean he features against Partizan.
Brandon Williams has impressed in his outings at left-back and must also be under consideration, while Phil Jones started in the away game in the Serbian capital and will hope for some more minutes at centre-back.