The Reds won 3-2 at the Amex Stadium at the weekend but both teams are set to have a different look when the Carabao Cup fourth-round clash kicks off at 19:45 BST on Wednesday night.
Ole Gunnar Solskjaer made 10 alterations to his line-up for last week's 3-0 victory at Luton Town, with only skipper Harry Maguire retained. The boss said at Kenilworth Road that the centre-back always wants to play and it would be no surprise if he led the team out again in midweek.
Ole suggested he will make “some changes” for this latest encounter with the Seagulls, which could mean Dean Henderson keeping goal after his clean sheet on his debut for the club at Luton.