Ole Gunnar Solskjaer's men are three points clear of the champions at the Premier League summit, and four ahead of third-placed Manchester City, who closed the gap with a narrow 1-0 home victory against Brighton & Hove Albion on Wednesday.
Both Ole and Jurgen Klopp face an anxious wait on the fitness of several key players before any plans can be finalised at the weekend.
Anthony Martial and Nemanja Matic appeared to sustain knocks in the closing stages of the tense 1-0 win over Burnley, with the pair leaving the field before time was up at Turf Moor.