Erik ten Hag's Reds, fresh from the Wembley win over Newcastle United, face the Hammers for a place in the last eight of the Emirates FA Cup.
The 19:45 GMT kick-off could present an opportunity for the boss to make a few changes, ahead of Sunday's big Premier League clash at Liverpool, but he has always stated the need to keep the foot firmly on the accelerator in the bid to keep competing on four fronts.
Hence, the only players definitely out would appear to be Donny van de Beek and Christian Eriksen, who said he should be rid of his protective boot soon, with Anthony Martial a doubt after still being sidelined for Sunday's Carabao Cup final.