Erik ten Hag's side did superbly to eliminate Barcelona over two legs in the play-off round and now face another team from La Liga, who sit fifth in the table and earned a goalless draw with Real Madrid on Sunday.
It promises to be another stern test for the Reds, on the road to Budapest, with the second leg to come at the impressive Estadio Benito Villamarin, which houses more than 60,000 spectators.
There must be a temptation for the manager to make changes, after he labelled the performance "unprofessional" at Liverpool, but also a likelihood that he will act rationally in response to the 7-0 defeat, particularly given the form of the side prior to the chastening experience on Merseyside.