The Spaniard, who joined the Reds from Atletico Madrid back in June 2011, will become just the 11th player in our history to reach the milestone when he takes to the field at Old Trafford.
De Gea joins Ryan Giggs, Sir Bobby Charlton, Paul Scholes, Bill Foulkes, Gary Neville, Wayne Rooney, Alex Stepney, Tony Dunne, Denis Irwin and Joe Spence in achieving the feat, with Stepney being the only keeper ahead of the 31-year-old in our all-time appearances list.
David has won the Premier League, FA Cup, EFL Cup and Europa League during his time in Manchester, plus numerous individual accolades, including the Sir Matt Busby Player of the Year award, which he has claimed a joint-record four times.