The boss has made two changes from Tuesday night's 3-2 reverse against Galatasaray, with Jonny Evans and Harry Maguire both coming in to the side.
Hannibal and Raphael Varane are the players replaced and, while the former is on the bench today, Rapha misses out completely.
Saturday's visitors are chasing their first win at Old Trafford since 1937 but Thomas Frank is having to cope without seven players, including key defenders Ben Mee and Rico Henry, plus the suspended Ivan Toney.
The Bees have won one of their opening seven Premier League fixtures, with that victory coming back in August at Fulham.