The Reds beat League One side Wigan Athletic 2-0 in the Emirates FA Cup on Monday, but this is our first game of the year in the top flight.
Christian Eriksen, who was ill for the trip to the DW Stadium, replaces Scott McTominay in the line-up.
McTominay takes a place on the bench, alongside Casemiro and Lisandro Martinez, who are returning to the matchday squad following long absences.
Casemiro hasn't played since the Carabao Cup meeting with Newcastle United on 1 November. Martinez, meanwhile, has been absent for almost four months - our 4-3 defeat to Bayern Munich on 20 September was his last outing.