The boss revealed in Wednesday's press conference that Lee Grant, Di'Shon Bernard, Ethan Laird and Dylan Levitt would all start in the Europa League clash. Experienced keeper Grant is set to make his full debut for the club, while the others have their very first involvement with the senior side.
Luke Shaw returns at left-back following a hamstring problem, while Jesse Lingard captains the team for the first time and Mason Greenwood spearheads the attack.
Nine of the team have come through United's famous Academy, as have all seven substitutes, including Max Taylor, who recently returned to football after receiving cancer treatment.