The United manager has made three changes to the side that drew with Wolves before the winter break and it appears he is going for five at the back with Harry Maguire, Eric Bailly – making his first appearance of the season after injury – and Luke Shaw at the heart of the defence in front of David De Gea. Aaron Wan-Bissaka and Brandon Williams will provide support in the wingback positions.
It's been confirmed by the club that Victor Lindelof has not travelled due to illness.
Ahead of them, Fred and Nemanja Matic, who returns from a one-match suspension, anchor the midfield while Bruno Fernandes, playing in his first away game for the Reds, lines up in attack with Daniel James and Anthony Martial.