There is just one change from the starting XI that was named for last weekend's 2-2 draw at Bournemouth, with Scott McTominay coming in for young Willy Kambwala.
It remains to be seen if McTominay will directly replace Kambwala in the back four, with Casemiro another player that could potentially move back from a conventional midfield role.
Andre Onana starts in goal, with Diogo Dalot and Aaron Wan-Bissaka expected to play as full-backs in a defence that includes Harry Maguire, who seems to have overcome the injury issue that he had at Bournemouth.