Our captain has missed the last three matches since picking up a problem in the defeat to Aston Villa just before Christmas, but returns to skipper the side in the 20:15 GMT kick-off at Turf Moor.
Fernandes comes in for Leny Yoro, who is named on a substitutes' bench that also features the returning Harry Maguire, Kobbie Mainoo and Mason Mount.
Their inclusions are a pre-match boost for Fletcher, who suggested in Tuesday's press conference that Fernandes and Mount would be in the squad this evening.
The presence of Maguire and Mainoo is also a welcome sight that we reported as the squad arrived in east Lancashire, a short time ago.