The Brazil midfielder was booked in the second half of the dramatic 4-4 draw with Bournemouth at Old Trafford, for a trip on Marcus Tavernier, as the Cherries man advanced towards goal.
To make matters worse, Tavernier scored from the resulting free-kick to edge the visitors 3-2 ahead.
It was a fifth caution in the top-flight campaign for Casemiro this term, ensuring he is out of Sunday's 16:30 GMT encounter at Villa Park.
The experienced midfielder, who also scored with a far-post header on Monday night, is a key figure in Ruben Amorim's side but he was also banned for the game at Brentford in September, which we lost 3-1, following a red card in the home win over Chelsea.