Michael Carrick's side are looking to maintain momentum and build on the spectacular back-to-back victories over the top two sides in the Premier League.
The 2-0 Manchester derby win over City was followed by Sunday's outstanding 3-2 triumph at Arsenal, ending the leaders' unbeaten home record in all competitions.
The clash with Fulham will pose a fresh challenge for the Reds, with the in-form Cottagers themselves moving up to seventh spot in the table.
United's six-game run in the division without a defeat is actually the longest of any team.
Although we have lost only one of our last 20 league meetings with the Cottagers, they did knock us out of last season's Emirates FA Cup at Old Trafford, and Marco Silva's men are on a good run.