First in action are Darren Fletcher's Under-18s, who have made an impressive start to the Academy campaign. The youngsters are away to Derby County in the league, with a 12:00 BST kick-off time on Saturday afternoon.
The game at Derby's Training Centre at Moor Farm is not being covered live, but we will be providing match details afterwards on the United App and ManUtd.com.
Ruben Amorim's side then take on Burnley at Old Trafford, in the traditional 15:00 BST slot.
Although the Premier League fixture is not being broadcast live in the UK, you can follow every kick via our live commentary service.