Coach Thomas Tuchel has lost the services of former Arsenal forward Serge Gnabry, who was injured in the shock 5-1 defeat at Eintracht Frankfurt on Saturday.
Goalkeeper Sven Ulreich has sustained an ankle problem and is unavailable, with Manuel Neuer, who played excellently against us in the semi-finals in 2010/11 for Schalke, back between the posts.
Harry Kane is expected to lead the line and he is looking to be the first Englishman to score against the Reds at Old Trafford in the competition.
There is no Matthijs De Ligt, who played under Erik ten Hag at Ajax, as the centre-back is currently undergoing individual training in Munich.