It follows our opening victory over Norwegian outfit Valerenga last week at the Progress with Unity Stadium, as we look to build on that perfect start.
The match comes as our first away trip of the competition proper, against an Atletico side who have also made a productive opening to their European campaign.
Here's everything you need to know ahead of the game...
HOW TO WATCH AND FOLLOW
Our 17:45 BST kick-off against Las Rojiblancas is set to be streamed live on Disney+, the rights holder for the Women's Champions League from this season.