The Netherlands international was one of two un-named players flagged as doubts before kick-off by the boss during his pre-match press conference at Carrington.
It is the first game he has missed all season, having played every minute of Premier League action and coming on as a substitute in the Carabao Cup tie against Grimsby Town.
Amorim does hope the problem will not keep the centre-back out of action for too long, with Wolverhampton Wanderers up next on Monday night.
A busy spell follows throughout the month as the festive calendar ramps up.