The Selhurst Park showdown kicks off at 12:00 GMT, with the Reds desperate to respond positively to Monday night's setback against Everton.
Matheus Cunha missed the 1-0 defeat to the Toffees and is set to be absent again this weekend.
Harry Maguire and Benjamin Sesko willl also remain on the sidelines.
"Sesko is going to take a little bit more time," explained Ruben, during his pre-match press conference at Carrington on Friday.
"It will take a little bit longer and we are taking care of him.
"Harry, the same. I expect to have Matheus in the next one [West Ham United on Thursday], not this one.