Lisandro Martinez is back in the squad for the first time since early February, and is joined on the bench by youngster Shea Lacey, who gets a maiden call at senior level.
With Matheus Cunha out, Joshua Zirkzee looks set to lead the line, after scoring twice in this fixture last season.
Amad again starts in a more advanced role, with Bryan Mbeumo on the opposite flank, while Leny Yoro is drafted into the three-man defence to replace Harry Maguire.
As expected there is also no Benjamin Sesko, but Kobbie Mainoo is fit enough to be among the substitutes.