The young Reds produced a hard-fought victory over Derby County in the third round at Old Trafford when Ethan Williams came off the bench to score the game’s only goal.
The winner of Tuesday’s encounter — a 19:00 GMT kick-off — will travel to Gillingham or Sunderland in the fifth round.
Subscribers in the UK and Ireland can watch the match live on MUTV, where coverage begins 15 minutes before kick-off.
Hugill signs new contract, joins Burton on loan
Joe Hugill has joined League One club Burton Albion on loan until the end of the 2023/24 season.