The San Diego showdown with the Welsh side, co-owned by actors Ryan Reynolds and Rob McElhenney, kicks off at 03:30 BST on Wednesday.
The intention was always for it to be a youthful Reds line-up, with a game to come on the following day, against Real Madrid, hence it will be unusual to have such exposure to a senior match but it should provide valuable experience to those involved.
Of course, there is still much development in the pipeline for the youngsters but some 32 Academy players supported first-team training last season, and this can be viewed as another step in the learning process.